Fentanyl CAS 437-38-7

Fentanyl CAS 437-38-7

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Fentanyl CAS 437-38-7 sistematik (IUPAC) Nama N- (1- (2-phenylethyl) -4-piperidinyl) -N-phenylpropanamide nama Dagangan data klinikal Actiq, Duragesic, Fentora, Sublimaze dan lain-lain AHFS / Drugs.com monograf kategori kehamilan AU: C Amerika Syarikat: C (Risiko tidak menolak) Legal AU status: S8 (Kawalan) DE: Anlage III UK: Kelas A US: Jadual II? (Penetapan sahaja) liabiliti Kebergantungan Laluan Sangat tinggi TD pentadbiran, IM, IV, transmucosal lisan, sublingual, buccal Farmakokinetik Bio dalam data 92% (transdermal) 89% (intranasal) 50% (buccal) 33% (pemakanan) Protein mengikat 80- 85% Metabolisme hepatik, terutamanya ...

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Fentanyl hcl

Fentanyl CAS 437-38-7

Sistematik (IUPAC) Nama N- (1- (2-phenylethyl) -4-piperidinyl) -N-phenylpropanamide Klinikal nama Dagangan data Actiq, Duragesic, Fentora, Sublimaze dan lain-lain AHFS / Drugs.com kategori monograf Kehamilan AU: C Amerika Syarikat: C (Risiko tidak menolak) Legal AU status: S8 (Kawalan) DE: Anlage III UK: Kelas A US: Jadual II? (Penetapan sahaja) liabiliti Kebergantungan Laluan Sangat tinggi TD pentadbiran, IM, IV, transmucosal lisan, sublingual, buccal Farmakokinetik Bio dalam data 92% (transdermal) 89% (intranasal) 50% (buccal) 33% (pemakanan) Protein mengikat 80- 85% Metabolisme hepatik, terutamanya oleh CYP3A4 Permulaan tindakan 5 min [1] biologi separuh hayat (IV) = 10-20 minit (T1 / 2 β) 2-4 jam (T1 / 2?) intranasal = 6.5 minit Transdermal = 20-27 h [2] Sublingual / buccal (dos tunggal) = 5,4-6,3 h Tempoh tindakan IV = 30-60 minit 30-40 min perkumuhan 60% kencing (metabolit, <dadah 10% tidak berubah) Pengenal pasti CAS Nombor 437- 38-7 kod Ya ATC N01AH01 N02AB03 PubChem CID: 3345 IUPHAR / BPS 1626 DrugBank DB00813 Ya ChemSpider 3228 Ya Unii UF599785JZ Ya Kegg D00320 Ya Chebi Chebi: 119.915 Ya ChEMBL CHEMBL596 Ya Chemical data Formula C22H28N2O Molekul massa 336,471 g / mol SMILES [tunjukkan] Inchi [tunjukkan] takat lebur data fizikal 87.5 ° C (189,5 ° F)

Fentanyl (also known as fentanil, brand names Sublimaze,Actiq, Durogesic, Duragesic, Fentora, Matrifen, Haldid, Onsolis,Instanyl,Abstral,Lazanda and others) is a potent, synthetic opioid analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors. Historically, it has been used to treat breakthrough pain and is commonly used in pre-procedures as a pain reliever as well as an anesthetic in combination with a benzodiazepine.

Fentanyl adalah kira-kira 80 hingga 100 kali lebih kuat daripada morfin dan kira-kira 40 hingga 50 kali lebih kuat daripada gred farmaseutikal (100% tulen) heroin.

工厂5

Fentanyl,fentanilo,sufentanyl,phentanyl,fantanyl


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