Fentanyl CAS 437-38-7

Fentanyl CAS 437-38-7

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Fentanyl CAS 437-38-7 Systematic (IUPAC) name N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide Clinical data Trade names Actiq, Duragesic, Fentora, Sublimaze and others AHFS/Drugs.com monograph Pregnancy category  AU: C US: C (Risk not ruled out) Legal status  AU: S8 (Controlled) DE: Anlage III UK: Class A US: Schedule II ? (Prescription only) Dependence liability Very high Routes of administration TD, IM, IV, oral transmucosal, sublingual, buccal Pharmacokinetic data Bioavailability 92% (transdermal) 89% (intranasal) 50% (buccal) 33% (ingestion) Protein binding 80–85% Metabolism hepatic, primarily…

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Fentanyl hcl

Fentanyl CAS 437-38-7

Systematic (IUPAC) name N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide Clinical data Trade names Actiq, Duragesic, Fentora, Sublimaze and others AHFS/Drugs.com monograph Pregnancy category  AU: C US: C (Risk not ruled out) Legal status  AU: S8 (Controlled) DE: Anlage III UK: Class A US: Schedule II ? (Prescription only) Dependence liability Very high Routes of administration TD, IM, IV, oral transmucosal, sublingual, buccal Pharmacokinetic data Bioavailability 92% (transdermal) 89% (intranasal) 50% (buccal) 33% (ingestion) Protein binding 80–85% Metabolism hepatic, primarily by CYP3A4 Onset of action 5 min[1] Biological half-life (IV)= 10–20 mins (T1/2 β) 2–4 hours (T1/2 ?) Intranasal = 6.5 mins Transdermal = 20–27 h[2] Sublingual/buccal (single dose) = 5.4–6.3 h Duration of action IV = 30–60 minutes 30–40 min Excretion 60% Urinary (metabolites, <10% unchanged drug) Identifiers CAS Number 437-38-7 Yes ATC code N01AH01 N02AB03 PubChem CID: 3345 IUPHAR/BPS 1626 DrugBank DB00813 Yes ChemSpider 3228 Yes UNII UF599785JZ Yes KEGG D00320 Yes ChEBI CHEBI:119915 Yes ChEMBL CHEMBL596 Yes Chemical data Formula C22H28N2O Molecular mass 336.471 g/mol SMILES[show] InChI[show] Physical data Melting point 87.5 °C (189.5 °F)

Fentanyl (also known as fentanil, brand names Sublimaze,Actiq, Durogesic, Duragesic, Fentora, Matrifen, Haldid, Onsolis,Instanyl,Abstral,Lazanda and others) is a potent, synthetic opioid analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors. Historically, it has been used to treat breakthrough pain and is commonly used in pre-procedures as a pain reliever as well as an anesthetic in combination with a benzodiazepine.

Fentanyl is approximately 80 to 100 times more potent than morphine and roughly 40 to 50 times more potent than pharmaceutical grade (100% pure) heroin.

工厂5

Fentanyl,fentanilo,sufentanyl,phentanyl,fantanyl


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