Orlistat,Xenical,Alli CAS 96829-58-2

Orlistat,Xenical,Alli CAS 96829-58-2

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Orlistat,Xenical,Alli CAS 96829-58-2 Orlistat is a drug designed to treat obesity. It is marketed as a prescription drug under the trade name Xenical by Roche in most countries, and is sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States.Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for…

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Orlistat,Xenical,Alli CAS 96829-58-2

Orlistat is a drug designed to treat obesity. It is marketed as a
prescription drug under the trade name Xenical by Roche in most
countries, and is sold over-the-counter as Alli by GlaxoSmithKline in the
United Kingdom and the United States.Its primary function is preventing
the absorption of fats from the human diet by acting as a lipase inhibitor,
thereby reducing caloric intake. It is intended for use in conjunction with
a healthcare provider-supervised reduced-calorie diet.

Orlistat is the saturated derivative of lipstatin, a potent natural inhibitor
of pancreatic lipases isolated from the bacterium Streptomyces
toxytricini.However, due to its relative simplicity and stability, orlistat was
chosen over lipstatin for development as an anti-obesity drug.

The effectiveness of orlistat in promoting weight loss is definite but
modest. Pooled data from clinical trials suggest that people given orlistat
in addition to lifestyle modifications, such as diet and exercise, lose about
2–3 kilograms (4.4–6.6 lb) more than those not taking the drug over the
course of a year.Orlistat also modestly reduces blood pressure and
appears to prevent the onset of type 2 diabetes, whether from the weight
loss itself or to other effects. In a large randomized controlled trial,
orlistat was found to reduce the incidence of diabetes by nearly 40% in
obese people.

Benefits aside, however, orlistat is notorious for its gastrointestinal side
effects (sometimes referred to as treatment effects), which can include
steatorrhea (oily, loose stools). They decrease with time, however, and are
the most frequently reported adverse effects of the drug.In the United
States and the European Union, orlistat is available for sale without a
prescription. Over-the-counter approval was controversial in the United
States, with consumer advocacy group Public Citizen repeatedly opposing
it on safety and efficacy grounds.Generic formulations of orlistat are
available in some countries. In Australia it is listed as an S3 medication
and so is available over the counter in pharmacies.

Orlistat,Xenical,Alli,orlistate,uristate,zenical,aslli

Orlistat,Xenical,Alli,orlistate,uristate,olistat,zenical,xencal

Orlistat,Xenical,Alli CAS 96829-58-2

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