Fentanil CAS 437-38-7

Fentanyl CAS 437-38-7

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Fentanyl CAS 437-38-7 Systematic (IUPAC) name N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide Clinical data Trade names Actiq, Duragesic, Fentora, Sublimaze and others AHFS/Drugs.com monograph Pregnancy category  AU: C US: C (Risk not ruled out) Legal status  AU: S8 (Controlled) DE: Anlage III UK: Class A US: Schedule II ? (Prescription only) Dependence liability Very high Routes of administration TD, IM, IV, oral transmucosal, sublingual, buccal Pharmacokinetic data Bioavailability 92% (transdermal) 89% (intranasal) 50% (buccal) 33% (ingestion) Protein binding 80–85% Metabolism hepatic, primarily…

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Fentanyl hcl

Fentanyl CAS 437-38-7

Systematic (IUPAC) name N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide Clinical data Trade names Actiq, Duragesic, Fentora, Sublimaze and others AHFS/Drugs.com monograph Pregnancy category  AU: C US: C (Risk not ruled out) Legal status  AU: S8 (Controlled) DE: Anlage III UK: Class A US: Schedule II ? (Prescription only) Dependence liability Very high Routes of administration TD, IM, IV, oral transmucosal, sublingual, buccal Pharmacokinetic data Bioavailability 92% (transdermal) 89% (intranasal) 50% (buccal) 33% (ingestion) Protein binding 80–85% Metabolism hepatic, primarily by CYP3A4 Onset of action 5 min[1] Biological half-life (IV)= 10–20 mins (T1/2 β) 2–4 hours (T1/2 ?) Intranasal = 6.5 mins Transdermal = 20–27 h[2] Sublingual/buccal (single dose) = 5.4–6.3 h Duration of action IV = 30–60 minutes 30–40 min Excretion 60% Urinary (metabolites, <10% unchanged drug) Identifiers CAS Number 437-38-7 Yes ATC code N01AH01 N02AB03 PubChem CID: 3345 IUPHAR/BPS 1626 DrugBank DB00813 Yes ChemSpider 3228 Yes UNII UF599785JZ Yes KEGG D00320 Yes ChEBI CHEBI:119915 Yes ChEMBL CHEMBL596 Yes Chemical data Formula C22H28N2O Molecular mass 336.471 g/mol SMILES[show] InChI[show] Physical data Melting point 87.5 °C (189.5 °F)

Fentanil (aynı zamanda fentanil olarak da bilinen, marka isimleri Sublimaze, Actiq, Durogesic, Duragesic, Fentora, Matrifen, Haldid, Onsolis, Instanyl, abstral, Lazanda ve diğerleri) bir etkinin hızla başlaması ve kısa süreli etkili bir sentetik opioid analjeziktir. Bu μ-opioid reseptörlerde kuvvetli bir agonistidir. Tarihsel olarak, ağrıyı tedavi etmek için kullanılan ve genel olarak, bir ağrı kesici olarak bir benzodiazepin ile kombinasyon halinde bir anestetik olarak ön işlemler kullanılır.

Fentanyl is approximately 80 to 100 times more potent than morphine and roughly 40 to 50 times more potent than pharmaceutical grade (100% pure) heroin.

工厂 5

Fentanyl,fentanilo,sufentanyl,phentanyl,fantanyl


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